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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
25.15
Human Site:
Y64
Identified Species:
39.52
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
Y64
V
T
Q
Q
M
W
V
Y
D
E
D
V
G
I
N
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y93
L
T
Q
F
M
W
V
Y
D
E
D
V
G
M
N
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y80
L
T
Q
F
M
W
V
Y
D
E
D
V
G
M
N
Dog
Lupus familis
XP_537646
1532
174610
Y64
V
T
Q
Q
M
W
V
Y
D
E
D
I
G
M
N
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
Y63
V
T
Q
Q
M
W
V
Y
D
E
D
V
G
I
N
Rat
Rattus norvegicus
P41516
1526
173202
Y63
V
T
Q
Q
M
W
V
Y
D
E
D
V
G
I
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
F92
L
T
Q
Q
M
W
V
F
D
E
D
A
G
L
N
Chicken
Gallus gallus
O42130
1553
174974
F65
V
T
Q
Q
M
W
V
F
D
E
D
V
G
L
N
Frog
Xenopus laevis
NP_001082502
1579
178601
F62
V
T
Q
Q
M
W
V
F
D
E
D
E
G
L
N
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
F63
V
T
Q
Q
M
W
V
F
D
E
D
T
G
M
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
K54
S
Q
N
R
M
V
Q
K
E
I
S
F
V
P
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
V97
T
E
K
T
P
M
W
V
Y
N
M
E
E
S
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
V90
F
T
E
T
M
W
V
V
D
D
G
V
M
V
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
Y65
H
T
Q
T
L
W
V
Y
E
K
D
E
M
V
Q
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
I56
M
I
E
K
N
V
T
I
V
P
G
L
F
K
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
80
80
86.6
N.A.
100
100
N.A.
73.3
86.6
80
80
N.A.
6.6
N.A.
0
46.6
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
93.3
100
93.3
93.3
N.A.
20
N.A.
6.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
74
7
74
0
0
0
0
% D
% Glu:
0
7
14
0
0
0
0
0
14
67
0
20
7
0
0
% E
% Phe:
7
0
0
14
0
0
0
27
0
0
0
7
7
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
14
0
67
0
7
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
7
0
7
0
7
0
20
7
% I
% Lys:
0
0
7
7
0
0
0
7
0
7
0
0
0
7
7
% K
% Leu:
20
0
0
0
7
0
0
0
0
0
0
7
0
20
0
% L
% Met:
7
0
0
0
80
7
0
0
0
0
7
0
14
27
0
% M
% Asn:
0
0
7
0
7
0
0
0
0
7
0
0
0
0
74
% N
% Pro:
0
0
0
0
7
0
0
0
0
7
0
0
0
7
0
% P
% Gln:
0
7
74
54
0
0
7
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
7
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% S
% Thr:
7
80
0
20
0
0
7
0
0
0
0
7
0
0
0
% T
% Val:
47
0
0
0
0
14
80
14
7
0
0
47
7
14
0
% V
% Trp:
0
0
0
0
0
80
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _